• อังกฤษ

  • Buffaloes;Buffalo calves;Ofloxacin;Pharmacokinetics;Urinary excretion;India

  • Pharmacokinetics and urinary excretion of ofloxacin were determined in male buffalo calves following single intramuscular administration (5 mg/kg). The disposition of ofloxacin followed a one-compartment open model after the absorption phase following a single i.m. injection. The drug was rapidly the absorbed and at 5 minutes, the concentration was 2.55 micro g/ml. The peak plasma level was 3.78 micro g/ml at 30 minutes, this declined gradually to 0.54 micro g/ml at 360 minutes. The drug remained above the minimum therapeutic concentration (MIC90: 0.5 micro g/ml) for 6 h. The absorption rate constant (ka) was 3.70 1/h with an absorption half life (t1/2ka) of 0.19 h. The observed peak plasma concentration (Cmax) was 3.78 micro g/ml at 30 minutes (tmax). The drug was not detected in plasma after 6 h, as also indicated by a high value of the elimination rate constant (beta: 0.367 1/h) and a short biological half life (t1/2 beta: 1.91 h). The volume of distribution (Vz(area): 0.69 L/kg) revealed moderate to good distribution and tissue penetration of ofloxacin. The total body clearance (ClB) was 0.25 L/kg/h. The area under plasma concentration curve (AUC) was 12.40 micro g/ml.h. About 54 percent of the total administered dose of ofloxacin was excreted in urine in 48 h. An optimal dosage regimen of ofloxacin following a single intramuscular injection in buffalo calves would be 6.5 mg/kg followed by 6 mg/kg at 8 h intervals to maintain a minimum therapeutic concentration of 0.5 micro g/ml suitable for the treatment of systemic infections in buffalo calves.

  • [1] Sandeep Kumar (CCS Haryana Agricultural University, Hisar Haryana (India). College of Veterinary Sciences, Department of Pharmacology and Toxicology)
    [2] Punia, J.S. (CCS Haryana Agricultural University, Hisar Haryana (India). College of Veterinary Sciences, Department of Pharmacology and Toxicology)
    [3] Jain, S.K. (CCS Haryana Agricultural University, Hisar Haryana (India). College of Veterinary Sciences, Department of Pharmacology and Toxicology)

83 38

  ไฟล์ดิจิทัล

  Export

  ค้นเพิ่มเติม

Sandeep Kumar. (2009). Disposition kinetics and urinary excretion of ofloxacin following intramuscular administration in buffalo calves.  Buffalo Bulletin (Thailand), 28 (3) ,154-158


Sandeep Kumar. "Disposition kinetics and urinary excretion of ofloxacin following intramuscular administration in buffalo calves" Buffalo Bulletin (Thailand), 28, 2009, 154-158.

Sandeep Kumar. (2009). Disposition kinetics and urinary excretion of ofloxacin following intramuscular administration in buffalo calves.  Buffalo Bulletin (Thailand), 28 (3) ,154-158